A Breakthrough in Hyperbaric Oxygen Therapy for Mild Traumatic Brain Injury (mTBI)


Mild traumatic brain injury (mTBI) and its associated post-concussive symptoms have become a significant concern in recent years. The National Brain Injury, Rescue and Rehabilitation Study aimed to explore the potential benefits of hyperbaric oxygen therapy (HBOT) in the treatment of chronic mTBI. This article provides an overview of the study design, outcomes, and implications.

Study Design

The study involved a multicenter observational approach, with 32 subjects diagnosed with chronic mTBI participating in the research. The participants underwent multiple HBOT sessions, administered in a hyperbaric chamber. The treatment protocol consisted of a series of sessions, each lasting for a specific duration and delivered at a specific pressure level.

The researchers carefully monitored the participants throughout the study, collecting data on various outcome measures, including self-reported symptoms, neurocognitive assessments, and imaging studies. The study duration ranged from six to twelve weeks, depending on the individual’s response to the treatment.

Results and Findings

The results of the study demonstrated promising improvements in neurocognitive deficits associated with chronic mTBI. Participants reported a reduction in post-concussive symptoms, including headaches, dizziness, memory problems, and cognitive impairments. Objective assessments, such as neurocognitive tests and imaging studies, also showed positive changes in brain function and structure.

Neurocognitive tests, such as the Trail Making Test and the Stroop Test, revealed significant improvements in attention, processing speed, and executive functions. These findings suggest that HBOT may enhance cognitive performance and alleviate the cognitive impairments commonly experienced by individuals with chronic mTBI.

Furthermore, imaging studies, including magnetic resonance imaging (MRI) and functional MRI (fMRI), demonstrated changes in brain activity and connectivity. The regions associated with cognitive functions, such as the prefrontal cortex and the hippocampus, showed increased activation and improved connectivity after the HBOT sessions. These neuroimaging findings support the hypothesis that HBOT can promote neuroplasticity and facilitate the healing process in the injured brain.


The findings of this study support the potential effectiveness of HBOT as a treatment modality for chronic mTBI. The hyperbaric oxygen environment appears to enhance oxygen delivery to the injured brain tissue, promoting neuroplasticity and facilitating the healing process. The observed improvements in neurocognitive deficits suggest that HBOT may have a significant impact on the recovery and rehabilitation of individuals with chronic mTBI.

HBOT is believed to exert its therapeutic effects through multiple mechanisms. The increased oxygen availability in the hyperbaric chamber helps to counteract the hypoxic state often observed in mTBI. Oxygen is a crucial element for cellular metabolism and energy production, and an adequate oxygen supply is essential for brain tissue to function optimally. By delivering oxygen under increased pressure, HBOT enhances oxygen diffusion and availability, which can support the metabolic needs of the injured brain.

In addition to its direct effects on oxygenation, HBOT has been shown to reduce inflammation and oxidative stress, which are common processes associated with brain injury. The pressurized oxygen environment can modulate the inflammatory response, suppress the release of pro-inflammatory cytokines, and promote the production of anti-inflammatory factors. This anti-inflammatory effect may contribute to the observed improvements in post-concussive symptoms and cognitive function.

It is important to note that HBOT is not a standalone treatment for mTBI. It should be integrated into a comprehensive rehabilitation program that includes other evidence-based therapies, such as cognitive rehabilitation, physical therapy, and psychological support. A multidisciplinary approach is crucial to addressing the complex and diverse symptoms experienced by individuals with chronic mTBI.

Furthermore, neuroimaging studies, such as MRI scans, showed changes in brain connectivity and neural activity patterns following HBOT. These changes were particularly evident in areas of the brain associated with attention, memory, and executive functions. The findings suggest that HBOT may have the potential to promote neuroplasticity and facilitate brain recovery in individuals with mTBI.

Implications and Future Directions

The National Brain Injury, Rescue and Rehabilitation Study provides valuable insights into the potential benefits of HBOT in the treatment of chronic mTBI. The findings suggest that HBOT may offer a non-invasive and safe therapeutic option for individuals experiencing persistent post-concussive symptoms.

The results of this study warrant further investigation through randomized controlled trials (RCTs) to establish the efficacy of HBOT with a larger sample size. RCTs would help to validate the findings and provide more robust evidence for the use of HBOT in the management of chronic mTBI.

It is important to note that HBOT should be considered as part of a comprehensive treatment approach for mTBI. Collaborative efforts between healthcare professionals specializing in brain injury rehabilitation are crucial for optimizing treatment outcomes.


The National Brain Injury, Rescue and Rehabilitation Study demonstrates the potential benefits of HBOT in the treatment of chronic mTBI. The findings suggest that HBOT may contribute to improvements in neurocognitive functioning and reduce post-concussive symptoms. However, further research is needed to confirm these findings and establish the efficacy of HBOT through rigorous randomized controlled trials.

Hyperbaric oxygen therapy shows promise as a non-invasive and safe treatment option for individuals with chronic mTBI. It offers hope for those experiencing persistent symptoms and highlights the importance of multidisciplinary approaches in brain injury rehabilitation.

Further Research Requirements

“Based on clinical observations and multi-year experience, a few other suggestions should be made about the protocol for any further studies.

  • The study population should include only subjects who have proven neuroimaging abnormalities.
  • To the extent practicable, subjects should not live at or be treated at elevations that complicate analysis of the effects of HBOT.
  • All drugs being ingested by subjects, as well as any and all additional therapies and interventions, should be carefully recorded throughout the entire study.
  • Funding should be provided for expanded endpoints: Brain perfusion MRI+DTI, brain SPECT and/or PET-CT, along with agreed-on computerized neuro-cognitive tests.
  • Additional endpoints should be considered: cost-effectiveness, quality of life as reported by subjects, families, and caregivers, and documented sustainability of HBOT treatment at six, twelve, and twenty-four months.”


Mozayeni BR, Duncan W, Zant E, Love TL, Beckman RL, Stoller KP. The National Brain Injury Rescue and Rehabilitation Study – a multicenter observational study of hyperbaric oxygen for mild traumatic brain injury with post-concussive symptoms. Med Gas Res. 2019 Jan-Mar;9(1):1-12. doi: 10.4103/2045-9912.254636. PMID: 30950414; PMCID: PMC6463441.