What Research Literature says about Hyperbaric Oxygen Therapy (HBOT) for Traumatic Brain Injury

Literature Review: Hyperbaric Oxygen Therapy (HBOT) for Traumatic Brain Injury


This literature review aims to provide a comprehensive summary of the research conducted on the effectiveness of Hyperbaric Oxygen Therapy (HBOT) in treating traumatic brain injury (TBI). The review encompasses various studies and aims to present a comprehensive overview of the current understanding of Hyperbaric Oxygen Therapy’s efficacy in improving outcomes for TBI patients.


To conduct this literature review, a systematic search of relevant databases was performed, including PubMed, Scopus, and Google Scholar. The search terms included “hyperbaric oxygen therapy,” “traumatic brain injury,” and related keywords. The inclusion criteria for studies were limited to those published within the last ten years and written in English.

After screening the initial search results, a total of 20 studies were selected for inclusion in this review. These studies consisted of randomized controlled trials, observational studies, and meta-analyses. The selected studies provided insights into the effectiveness of HBOT in improving various outcomes in TBI patients.

Key Findings

The reviewed studies consistently demonstrated promising results regarding the efficacy of Hyperbaric Oxygen Therapy (HBOT) in TBI patients. The number of Hyperbaric Oxygen Therapy (HBOT) sessions identified across the studies ranged from 20 to 40 sessions, with an average of 30 sessions being the most commonly recommended protocol.

  1. Cognitive Function: Several studies reported significant improvements in cognitive function following HBOT. Patients showed enhancements in memory, attention, and executive functioning. These improvements were observed both immediately after treatment and during follow-up assessments.
  2. Neurological Status: HBOT was found to have positive effects on neurological status. Studies reported improvements in motor function, sensory perception, and overall neurological recovery in TBI patients who received HBOT compared to those who did not.
  3. Quality of Life: HBOT was associated with improvements in the quality of life for TBI patients. Patients reported reduced symptoms of depression, anxiety, and improved overall well-being after undergoing Hyperbaric Oxygen Therapy sessions.
  4. Neuroplasticity and Brain Repair: Some studies suggested that HBOT may enhance neuroplasticity and promote brain repair processes. This could potentially contribute to long-term recovery and functional improvements in TBI patients.
  5. Safety and Side Effects: The reviewed studies consistently reported HBOT as a safe treatment option for TBI patients. Adverse effects were generally mild and transient, with no major complications reported.


Based on the literature review, HBOT shows promise as an effective treatment option for traumatic brain injury. The recommended number of HBOT sessions ranges from 20 to 40 sessions, with an average of 30 sessions being commonly suggested. HBOT has demonstrated positive effects on cognitive function, neurological status, and quality of life in TBI patients. Further research, including larger randomized controlled trials, is warranted to establish the optimal protocols and long-term benefits of HBOT in this population.

Published: July 31, 2023
Citation: Hadanny A, Maroon J,
et al., 2023. The Efficacy of
Hyperbaric Oxygen Therapy in
Traumatic Brain Injury Patients:
Literature Review and Clinical
Guidelines, Medical Research

Copyright: © 2023 European
Society of Medicine.

Please note that this article is for informational purposes only and should not replace professional medical advice. Consultation with a healthcare professional is essential before considering HBOT or any other medical treatment.